Table 1.

5-HTP and l-DOPA accumulation in brain regions of 5-HTT-overexpressing transgenic (Tg) and wild-type (Wt) mice

Frontal cortexStriatumHippocampus
WtTgWtTgWtTg
5-HTP (pmol/mg)0.83 ± 0.0380.79 ± 0.0531.1 ± 0.0511.1 ± 0.0932.5 ± 0.372.1 ± 0.30
l-DOPA (pmol/mg)0.84 ± 0.0740.94 ± 0.0853.8 ± 0.173.7 ± 0.340.79 ± 0.140.58 ± 0.092
  • Mice (n = 10 per group) were administered the aromatic amino acid decarboxylase inhibitor NSD 1015 (100 mg/kg) 30 min before tissue removal. The data shown are mean ± SEM values.