Average swim speeds (cm/s) of young and aged rats in the radial arm water maze after intracerebroventricular pregnenolone and 7α-hydroxypregnenolone administration
| Treatment | Trial 1 | Trial 2 | Trial 3 | Trial 4 | Trial 5 |
|---|---|---|---|---|---|
| Young (vehicle) | 17 ± 0.9 | 16 ± 0.5 | 22 ± 2.1 | 23 ± 1.2 | 23 ± 0.9 |
| Old (vehicle) | 17 ± 1.3 | 16 ± 1.1 | 18 ± 1.5 | 21 ± 1.1 | 20 ± 1.1 |
| Old (PREG) | 15 ± 0.9 | 15 ± 1.5 | 16 ± 1.2 | 20 ± 2.2 | 19 ± 1.6 |
| Old (7α-hydroxyPREG) | 17 ± 0.6 | 17 ± 1.0 | 19 ± 1.3 | 22 ± 2.2 | 21 ± 1.3 |
Data are mean ± SEM of the average swim speeds after 11 d of steroid treatment in the RAWM with a 30 min delay between trials 1 and 2 and no delays for trials 3–5.