Table 2.

Whole-cell current inactivation time constants

	Fast component^a			Slow component^a
	Actual WT-SCN1A	Model WT-SCN1A	Model R1648H	Actual WT-SCN1A	Model WT-SCN1A	Model R1648H
−30 mV	2.73 ± 0.49 [69 ± 18%]	2.20 [81%]	2.22 [86%]	6.4 ± 1.5 [31 ± 18%]	5.9 [19%]	7.0 [14%]
−20 mV	1.34 ± 0.18 [86 ± 5%]	1.04 [81%]	1.03 [83%]	5.5 ± 0.6 [14 ± 5%]	4.0 [19%]	3.8 [17%]
−10 mV	0.72 ± 0.06 [93 ± 1%]	0.62 [82%]	0.68 [87%]	6.0 ± 0.7 [7 ± 0.8%]	3.0 [18%]	3.3 [13%]
0 mV	0.47 ± 0.03 [94 ± 1%]	0.46 [87%]	0.46 [89%]	4.4 ± 0.5 [6 ± 0.7%]	2.8 [13%]	2.6 [11%]
10 mV	0.37 ± 0.02 [94 ± 1%]	0.32 [87%]	0.33 [89%]	3.9 ± 0.6 [6 ± 0.6%]	2.2 [13%]	2.2 [11%]
20 mV	0.31 ± 0.02 [92 ± 1%]	0.26 [89%]	0.23 [85%]	3.0 ± 0.3 [8 ± 1.2%]	1.9 [11%]	1.6 [15%]
30 mV	0.28 ± 0.02 [90 ± 1%]	0.20 [84%]	0.19 [83%]	2.7 ± 0.2 [10 ± 1.3%]	1.5 [16%]	1.4 [17%]

↵^aValues in brackets represent fractional amplitude.