Biophysical parameters for slow inactivation
| Onset of slow inactivationa | Voltage dependence of slow inactivation | Recovery from slow inactivationa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| τf(ms) | τs(ms) | Ir | n | V1/2(mV) | k (mV) | Ir | n | τf(ms) | τs(ms) | n | |
| Actual WT-SCN1A | 30 ± 7 [3 ± 1%] | 3029 ± 283 [83 ± 1%] | 14 ± 1 | 14 | −66.7 ± 2.0 | 7.8 ± 0.2 | 10 ± 1 | 11 | 238 ± 16 [65 ± 3%] | 2487 ± 240 [35 ± 3%] | 11 |
| Model WT-SCN1A | 30 [1%] | 2793 [84%] | 15 | −68.5 | 6.2 | 17 | 225 [63%] | 2647 [37%] | |||
| Model R1648H | 30 [1%] | 3112 [83%] | 16 | −68.6 | 6.1 | 18 | 221 [63%] | 2650 [37%] | |||
↵aValues in brackets represent amplitude.