Table 1.

Intrinsic electrophysiological properties of CA1 neurons recorded in brain slices prepared from B6 and Szt1 mice

Membrane propertyB6nSzt1n
Resting membrane potential (mV)−60.1 ± 0.419−59.7 ± 0.419
Holding current at −20 mV (pA)261 ± 2228280 ± 3131
Input resistance (MΩ)111 ± 438105 ± 440
Series resistance (MΩ)13.2 ± 0.53813.4 ± 0.540
Spike half-width (ms)1.52 ± 0.04191.53 ± 0.0418
Spike threshold (mV)−46.2 ± 0.719−45.0 ± 0.718
IK(M) deactivation kinetics (τ in ms)157 ± 1317140 ± 1517
  • None of the parameters measured differed between CA1 neurons in slices prepared from B6 and Szt1 mice (p > 0.5, ANOVA). Resting membrane potential, input resistance, and series resistance were taken from values reported by SealTest and MultiClamp Commander functions. Spike half-width and spike threshold values were calculated from the first action potential that was generated in response to the lowest depolarizing current injection. > values were calculated by fitting the IK(M) deactivation phase with a single-exponential equation.