Brain area | Experimental vs control tasks | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
STIM1 | t value | Delay (ISI) | t value | STIM2 | t value | |||||||
x | y | z | x | y | z | x | y | z | ||||
Left thalamus | −16 | −20 | 10 | 0.30 | −15 | −19 | 10 | 6.32 | −13 | −19 | 0 | 1.29 |
Right aIC/IFG | 39 | 17 | 7 | 3.78 | 39 | 14 | 4 | 4.92 | 36 | 20 | 4 | 3.42 |
Left ACC | −9 | 14 | 37 | 2.49 | −9 | 35 | 19 | 3.87 | −6 | 17 | 31 | 8.82 |
Right ACC | 8 | 2 | 32 | 2.09 | 7 | 23 | 34 | 3.72 | 9 | 26 | 24 | 2.82 |
Right pre-SMA | 12 | −4 | 49 | 3.04 | 0 | 11 | 49 | 5.83 | 9 | 8 | 46 | 7.93 |
Left VLPFC | −26 | 37 | 4 | 0.25 | −33 | 23 | 31 | 5.91 | −36 | 38 | 10 | 10.39 |
Right VLPFC | 39 | 41 | 4 | 2.04 | 45 | 41 | 13 | 5.98 | 27 | 47 | 4 | 6.92 |
In addition to activation areas observed during directed searches within the stimulus-related ROI, a number of other regions were noted with significant activity specific to encoding of sensory features of stimulus 1 (STIM1 period, experimental vs control trials), short-term memory (delay period, experimental vs control trials), or discrimination [stimulus 2 (STIM2) period, experimental vs control trials] of the noxious thermal stimuli [random-effects GLM analyses, global search of entire brain volume (threshold of significance, t = 4.7; p = 0.05, corrected for multiple comparisons)]. Stereotaxic coordinates are given in Talairach space (Talairach and Tournoux, 1988). IFG, Inferior frontal gyrus. t values in bold correspond to a p value of ≤0.05.