Table 1.

Demographic and clinical characteristics of genotypic subgroups

VariableCOMT genotypep
val/val (n = 16)met/met (n = 15)
Age64.3 (9.8)65.5 (9.6)0.75
Gender (male:female)11:59:60.72
Disease duration (years)3.9 (2.0)3.4 (1.5)0.41
UPDRS motor score22.2 (10.5)26.1 (9.4)0.29
MMSE28.9 (1.2)28.7 (0.8)0.59
Beck depression score6.8 (4.3)6.7 (4.5)0.99
NART (verbal IQ)113.1 (7.3)114.7 (6.2)0.50
Equivalent levodopa dose (mg)a618.8 (479.6)621.7 (430.6)0.99
Actual levodopa dose (mg)218.8 (152.6)313.3 (253.2)0.22
  • Mean (SD) tabulated unless otherwise stated. Between-group comparisons using Student's t or χ2 tests as appropriate. MMSE, Mini-Mental State Examination; NART, National Adult Reading Test.

  • aDerived from combined dopamine agonist and levodopa dose (see Materials and Methods).