Table 1.

Effects of 5-HT, α-methyl-5-HT, and ritanserin on cortical neurons

Drugs applied to the AI% Change in resp. at BFBF shift (kHz) elicited by:
15 min conditioning30 min conditioning
Saline−2.0 ± 1.0 (10/10)0.0 ± 0.1 (12/12)−1.8 ± 0.1 (10/10)
4 mm 5-HT−28.6 ± 4.8 (11/14)**−1.5 ± 0.2 (16/20)**Not studied
20 mm 5-HT−58.8 ± 4.3 (25/34)**0.0 ± 0.1 (12/12)−0.7 ± 0.1 (17/22)*
10 mm α-methyl-5-HT26.9 ± 5.6 (15/20)**−1.8 ± 0.2 (18/27)**−1.8 ± 0.2 (14/18)
10 mm ritanserin−20.5 ± 4.3 (16/19)*+1.0 ± 0.2 (10/12)*+1.0 ± 0.1 (18/23)**

  • ↵Changes in response magnitude and conditioning-elicited cortical BF shift evoked by 5-HT, α-methyl-5-HT, and ritanserin. Response (resp.) magnitude (number of spikes per 50 tone bursts) is expressed in percentage of change compared with the response in the control condition. A BF shift (mean ± SE) was either centripetal (negative) or centrifugal (positive). The numbers in parentheses are the number of neurons affected by a drug out of the total number of neurons studied. The drug effect is compared with the effect of saline (i.e., the control) for *p < 0.05 or **p < 0.01.