Table 1.

Effects of synaptic blockers on physiological properties of ON, OFF T, and OFF S RGCs

Vm ctrl (mV)Vm block (mV)Rn ctrl (MΩ)Rn block (MΩ)Rate ctrl (Hz)Rate block (Hz)CV ctrl (SD/mean)CV block (SD/mean)
ON−54.8 ± 2.7−65.5 ± 1.357.6 ± 2.657.3 ± 6.314.0 ± 3.50.61 ± 0.05
OFF T−60.3 ± 2.7−54.6 ± 1.058.6 ± 7.367.5 ± 6.614.3 ± 5.520.3 ± 3.00.54 ± 0.100.27 ± 0.03
OFF S−60.2 ± 2.1−55.1 ± 1.160.5 ± 6.7117.1 ± 15.916.6 ± 5.443.3 ± 3.50.33 ± 0.040.14 ± 0.01
n6, 7, 49, 7, 115, 7, 65, 6, 99, 7, 59, 8, 109, 5, 59, 8, 10
t test
ON-OFF TNS**NSNSNSNS
ON-OFF SNS**NS*NS**
OFF T-OFF SNSNSNS*NS**NS**

  • Shown are changes in measured Vm, input resistance (Rn), mean firing rate, and CV of interspike intervals for each cell type. ctrl, Control.

  • ↵*p < 0.05,

  • ↵**p < 0.01; NS, p ≥ 0.05. Data are mean ± SEM. For explanation of measurements, see Materials and Methods.