Table 1.

Intrinsic membrane properties of neurons recorded from GAERS and normal Wistar rats

Membrane resistance (MΩ)Time constant (ms)Action potential amplitude (mV)Action potential duration (ms)Action potential threshold (mV)
GAERS
    FocusLayer 2/327.5 ± 3.79.9 ± 2.556.5 ± 2.91.7 ± 0.1−50.6 ± 1.3
Layer 443.4 ± 3.2 1 14.2 ± 2.053.8 ± 4.91.8 ± 0.1−52.0 ± 2.8
Layer 5/621.7 ± 2.2 1 7.9 ± 0.957.8 ± 2.31.6 ± 0.1−53.6 ± 0.6
    MoCxLayer 5/625.8 ± 3.6 1 14.0 ± 2.560.4 ± 1.81.6 ± 0.1−53.2 ± 0.9
Wistar
    SoCxLayer 5/630.0 ± 4.16.5 ± 0.956.7 ± 1.11.8 ± 0.2−52.8 ± 1.2
  • Electrical parameters were measured in GAERS neurons, located in layer 2/3 (n = 6), layer 4 (n = 5), and layer 5/6 (n = 17) of the cortical focus and in layer 5/6 of motor cortex (MoCx; n = 9) and in nonepileptic Wistar rat somatosensory cortical neurons (SoCx; n = 7). All parameters were not significantly different (p > 0.05), except the membrane resistance of GAERS focus layer 4 neurons that was significantly higher than that of focus and motor cortex layer 5/6 cells (p < 0.001).