Table 2.

Effects of GLP-1 on firing rate, resting potential, and membrane resistance in the presence of synaptic blockers

ParameterControl100 nm GLP-1Washout
Resting potential (mV)−40 ± 2 (n = 7)−38 ± 2 (n = 7)*−40 ± 2 (n = 7)
Firing frequency (Hz)1.9 ± 0.8 (n = 7)2.5 ± 0.7 (n = 7)*1.6 ± 0.5 (n = 7)
Membrane resistance (GΩ)2.2 ± 0.16 (n = 7)2.0 ± 0.2 (n = 7)*2.2 ± 0.2 (n = 7)
Capacitance (pF)12 ± 1 (n = 7)
  • Experiments were carried out in the continued presence of 10 μm CNQX, 50 μm DAP5, and 100 μm picrotoxin to block synaptic currents. Parameters were measured from the same neurons first in control solution, then in the presence of 100 nm GLP-1, and finally 5 min after return to control solution. Numbers in parentheses give the number of cells recorded from.

  • *p < 0.05 versus control.