Pharmacological effects: mouse
| THIP | Gabazine | Aminophylline | Aminophylline plus gabazine | |
|---|---|---|---|---|
| RGC | (n = 6) | (n = 5) | (n = 8) | (n = 7) |
| Δ Holding current (pA) | −3.1 ± 7.5 | −0.5 ± 4.5 | −96.6 ± 35* | −26.6 ± 29.2 |
| Resting conductance (% of control) | 97.3 ± 29.5 | 83 ± 26 | 230 ± 86* | 138.9 ± 39* |
| SAC | (n = 9) | (n = 8) | (n = 9) | (n = 6) |
| Δ Holding current (pA) | −45.4 ± 34* | 48.7 ± 45* | −129.6 ± 84* | −8.8 ± 21.7 |
| Resting conductance (% of control) | 127.5 ± 74* | 108 ± 48* | 273 ± 120* | 99.5 ± 26 |
Summary of changes in holding current and resting conductance in mouse RGCs and SACs using the same conditions as Table 1. All data are shown as mean ± SD. Asterisks indicate statistical significance (p < 0.05).