The origin of interneuron subtypes from subpallial neuroepithelial domains identified by genetic fate mapping
| Subpallial germinal zone | Cre mice used for in vivo fate mapping (level of Cre activity) | Interneuron subtype |
|---|---|---|
| Central and ventral MGE | Nkx2.1–Cre (high) | SST+CR− |
| Lhx6–Cre (high) | PV+ | |
| Gsh2–Cre (low) | CB+ | |
| Nkx6.2–Cre (low) | ||
| Dorsal MGE | Nkx6.2–Cre (high) | CR+SST+ (Martinotti) |
| Lhx6–Cre (high) | NPY+ | |
| Nkx2.1–Cre (low) | ||
| Gsh2–Cre (low) | ||
| LGE/dorsal CGE | Gsh2–Cre (high) | CR+SST− (bipolar) |
| NPY+ |
Transgenic mice expressing Cre recombinase in distinct and overlapping domains were used to fate map neuroepithelial stem cell zones in vivo. Neurochemically distinct interneuron subtypes originate from discrete neuroepithelial domains identified by expression of molecular markers.