Summary statistics for overrepresented GO categories in each system and intersection between human HD caudate and models
| N1: common GO categories overrepresented at p < 0.05 in human HD | N2: common GO categories overrepresented at p < 0.05 in model | Intersection of N1 and N2 | p value | # GO categories with summed ranks ≤ 20 | # GO categories with summed ranks ≤ 200 | |
|---|---|---|---|---|---|---|
| Increasing genes | ||||||
| R6/2 | 166 | 127 | 14 | 0.036 | 2 | 12 |
| BDNF HET | 166 | 90 | 14 | 0.016 | 1 | 10 |
| BDNF KO | 166 | 196 | 22 | 0.014 | 0 | 10 |
| 3NP | 186 | 347 | 34 | 0.006 | 0 | 13 |
| MPTP | 148 | 81 | 4 | 0.726 | 0 | 4 |
| Decreasing genes | ||||||
| R6/2 | 294 | 230 | 50 | <0.001 | 1 | 20 |
| BDNF+/− | 294 | 94 | 22 | 0.009 | 0 | 15 |
| BDNF KO | 294 | 206 | 53 | <0.001 | 2 | 30 |
| 3NP | 327 | 101 | 11 | 0.405 | 0 | 4 |
| MPTP | 271 | 79 | 20 | <0.001 | 0 | 16 |
GO categories common to the separate human and model system pairs were identified. N 1 is the number of these common GO categories significantly increased or decreased in human caudate. N 2 is the number of common GO categories significantly affected in the indicated model. The number of common GO categories significantly over represented in both human HD and the indicated model is shown. p values for intersections were estimated by computer simulation. The number of GO categories in the intersections with summed ranks less than two arbitrary criteria are also shown.