Table 3.

Functional characterization of β₂97 mutant GABA_A receptors

Mutant	LogEC₅₀ ± SEM	EC₅₀ (μm)	EC_50mut/EC_50phe	n_H	n
α₁β₂	−5.457 ± 0.04	3.5		1.2	4
α₁β₂97-Phe	−6.190 ± 0.16^a	0.6	1	1.4	4
α₁β₂97-4-F-Phe	−4.706 ± 0.07^a	20	33	1.2	5
α₁β₂97-3,5-F₂-Phe	−3.372 ± 0.05^a	420	700	1.1	4
α₁β₂97-3,4,5-F₃-Phe	−2.002 ± 0.04^a	9900	16,500	1.9	5

↵^aDenotes logEC₅₀ values statistically significantly different from wild type by one-way ANOVA; p < 0.01.