Table 4.

Functional characterization of β2157 mutant GABAA receptors

MutantLogEC50 ± SEMEC50m)EC50mut/EC50wtnHn
α1β2−5.457 ± 0.043.51.24
α1β2157-Phe−2.846 ± 0.10a14004000.96
α1β2157-4-F-Phe−5.514 ± 0.153.00.861.26
α1β2157-3,5-F2-Phe−3.371 ± 0.04a4201202.04
α1β2157-3,4,5-F3-Phe−3.950 ± 0.08a110321.74
α1β2157-4-MeO-Phe−5.294 ± 0.1051.41.23
α1β2157-4-Me-Phe−3.817 ± 0.15a150430.83
  • aDenotes logEC50 values statistically significantly different from wild type by one-way ANOVA; p < 0.01.