Table 1.

Amount of wakefulness (W) and NREM and REM sleep after injections of BDNF, K252a, anti-BDNF, or corresponding vehicle

BDNF (n = 7)Vehicle (n = 7)K252a (n = 6)Vehicle (n = 6)Anti-BDNF (n = 7)(Vehicle) Anti-NT3 (n = 7)
NREM sleep (min)84.66 (±3.13)81.5 (±3.44)82.79 (±2.46)84.09 (±2.54)85.19 (±1.46)88.48 (±3.02)
REM sleep (min)11.12 (±1.08)10.92 (±2.15)11.32 (±1.87)14.28 (±1.17)12.07 (±1.45)16.22 (±1.31)
W (min)24.22 (±3.49)27.58 (±2.54)25.89 (±3.22)21.63 (±3.21)22.74 (±2.71)*15.3 (±3.36)*
Sleep latency (min)76.5 (±3.8)81.0 (±4.5)202.96 (±8.05)210.62 (±5.19)197.29 (±7.48)198.15 (±8.01)
  • Data are presented as mean ± SEM (in minutes) and refer to the first 2 h interval from sleep onset after the injections. Sleep latency is defined as the time between the start of the injection and the first consolidated sleep episode.

  • *p < 0.05, Wilcoxon's nonparametric test.