Table 1.

The properties of mIPSC in CA1 neurons undergoing SE

ParameterConSESE + Pep_3SE + Pep_3PPDBUPDBU + CalCCalC
Peak amplitude (pA) at 2 min46.6 ± 2.637.3 ± 1.836.2 ± 3.138.0 ± 3.3 35.3 ± 3.239.2 ± 3.536.0 ± 3.9
Peak amplitude (pA) at 22 min48.5 ± 3.839.5 ± 1.953.9 ± 7.5*38.4 ± 3.151.5 ± 4.6*40.6 ± 3.937.1 ± 4.1
10–90% rise time (ms)1.4 ± 0.11.4 ± 0.21.3 ± 0.21.4 ± 0.11.5 ± 0.11.4 ± 0.11.5 ± 0.2
τ decay (ms) at 2 min16.9 ± 1.117.4 ± 1.115.9 ± 0.916.3 ± 1.415.3 ± 0.914.6 ± 2.319.0 ± 0.5
τ decay (ms) at 22 min17.9 ± 0.918.3 ± 1.121.7 ± 1.3*18.2 ± 1.721.3 ± 1.9*16.2 ± 2.521.9 ± 0.9
Frequency2.1 ± 0.41.7 ± 0.22.1 ± 0.31.8 ± 0.41.2 ± 0.351.6 ± 0.31.2 ± 0.35
  • The kinetic parameters of mIPSCs of CA1 neurons in the absence and presence of peptides, PKC inhibitors, and activators were calculated at both 0 time and 20 min. In all panels, asterisks indicate significant difference from control (Con; p < 0.01; n = 8–12).