Table 1.

Main effects in fMRI of fear conditioning (CS+ > CS) in placebo and oxytocin groups and their interaction

Placebo groupOxytocin groupDifference placebo versus oxytocin group
Coordinatest valuep valueCoordinatest valuep valueCoordinatest valuep value
Dorsal/Ext Amy18, 2, −83.68<0.00120, 0, −82.75NS
Ant MTL16, 8, −243.70<0.05*
R Insula48, 4, 63.480.001
L Insula−36, 16, −103.72<0.001
vmPFC14, 46, −103.500.00116, 46, −103.660.001
vmPFC20, 56, −63.77<0.001
R lObfc44, 54, −124.51<0.00120, 56, −65.00<0.001
L lObfc−40, 52, −63.80<0.001
L ACC−14, 14, 403.63<0.001
R ACC10, 10, 423.95<0.00110, 10, 444.75<0.001
R rACC−12, 34, 123.58<0.0016, 46, 163.57<0.001
vlPFC48, 46, 23.64<0.001−50, 32, 84.13<0.001
  • Dorsal Amy, Dorsal amygdala; Ext Amy, extended amygdala; Ant MTL, anterior medial temporal lobe; vmPFC, ventromedial prefrontal cortex; vlPFC, ventrolateral prefrontal cortex; rACC, rostral anterior cingulate cortex; R, right; L, left; NS, nonsignificant. *Small volume corrected.