Changes of MSN firing rates with different types of dopamine responses
| Off | On | Dysk | |
|---|---|---|---|
| Unidirectional responses (50%) | |||
| ↑↑ (36%) | 21.1 (1.6) | 33.3* (2) | 44.1* (2.2) |
| ↓↓ (14%) | 33.6 (2.6) | 22.6* (2.2) | 16.5* (2.3) |
| Bidirectional responses (47%) | |||
| ↑↓ (27%) | 29.9 (2) | 47.9* (2.4) | 32.9* (2.6) |
| ↓↑ (20%) | 33.5 (2.4) | 20* (2) | 35.2* (2.8) |
Data derived from caudate and putamen MSNs pooled together. Units are grouped according to their response to dopamine stimulation as unidirectional [same direction of rate changes in the transition from the Off to the On and to the On-with-dyskinesias (Dysk) states] and bidirectional (inversion of the previous rate changes in the transition to the On-with-dyskinesias state). The successive changes of rate from one state to another are indicated by the arrows, and the percentage of neurons showing such a response is given in parenthesis. In each group, the mean rate (in hertz) is provided for each motor state (Off, On, and On with dyskinesias). Data are mean ± SEM.
↵*p < 0.0001 versus the previous state.