Otx2flox/flox | En1Cre/+; Otx2flox/flox | En1Cre/+; Otx2flox/flox + pCPA | Otx2flox/flox + pCPA | |
---|---|---|---|---|
No. of animals with generalized (stage 4–6) seizures | 10 of 10 | 1 of 10a | 10 of 10 | 10 of 10 |
Latency to first generalized (stage 4–6) seizure (min) | 18.9 ± 8.7b | 52c | 25 ± 7.9 | 32.3 ± 12.7 |
↵aThe number of animals with generalized seizures significantly differed between En1Cre/+; Otx2flox/flox and the other groups (z test, p < 0.001).
↵bLatency to the first generalized seizure is calculated from the time of KA administration. Values (in minutes) are reported as mean ± SD. Latency did not differ between Otx2flox/flox, Otx2flox/flox + pCPA, and En1Cre/+; Otx2flox/flox + pCPA mice (one-way ANOVA, p = 0.062).
↵cThe value reported refers to the only animal that showed a generalized seizure.