Table 3.

Age-related changes in brain volumes

RegionNeonate1 year2 yearPercentage change: 95% CI (neonate to 1 year)Percentage change: 95% CI (1 year–2 year)
ANOVAANCOVA (adjusted for TBV)ANOVAANCOVA (adjusted for TBV)
TBV425,387 (4806)855,540 (12,492)983,866 (15,393)95–107%*N/A11–19%*N/A
Cerebral hemispheres370,685 (4185)699,378 (10,199)804,501 (12,577)83–94%*−6 to −5%*11–19%*−1 to 1%
Cerebellum26,985 (371)91,962 (1712)105,154 (2084)228–253%*71–83%*10–19%*−1 to 9%
Subcortical + brainstem27,679 (453)64,214 (868)73,227 (1140)126–138%*18–22%*11–18%*−2 to 5%
Hemispheric gray206,480 (2396)514,048 (6679)588,441 (9100)143–155%*25–29%*11–18%*2–4%
Hemispheric white164,433 (1901)183,280 (4122)217,883 (5142)6–16%*−60 to −56%*13–24%*−24 to −4%
Lateral ventricles2109 (149)8069 (723)7406 (786)213–352%*−73 to −22%−28 to 11%−160 to −17%*
Right caudateN/A3221 (69)3778 (83)N/AN/A12–23%*1–11%
Left caudateN/A3012 (68)3607 (91)N/AN/A14–26%*3–15%
Right hippocampusN/A2113 (39)2377 (65)N/AN/A6–19%−4 to 7%
Left hippocampusN/A2075 (43)2367 (68)N/AN/A7–21%−6 to 6%
  • All volumes are mean (SD) in mm3. *p < 0.0001, p < 0.001, p ≤ 0.05.

  • N/A, Not applicable.