Table 1.

Effects of repeated saline/cocaine and challenge treatments

Day 1Day 7Challenge
Experiment 1: Effects of cocaine challenge on AMPAR sensitization
    Repeated saline-Veh/saline439.5 ± 92.7462.4 ± 69.7470.8 ± 81.7
    Repeated saline-CNQX/saline493.6 ± 68.6363.4 ± 31.9224.6 ± 34.7
    Repeated saline-Veh/cocaine493.3 ± 81.2340.7 ± 46.71186.7 ± 175.1*
    Repeated saline-CNQX/cocaine476.3 ± 82.1390.5 ± 55.61089.2 ± 149.5*
    Repeated cocaine-Veh/saline1896.5 ± 315.12860.5 ± 562.1457.6 ± 49.3
    Repeated cocaine-CNQX/saline1829.7 ± 298.62930.0 ± 312.3388.3 ± 50.0
    Repeated cocaine-Veh/cocaine1843.6 ± 331.52812.5 ± 384.92217.0 ± 240.5*
    Repeated cocaine-CNQX/cocaine1806.9 ± 351.02997.9 ± 461.51561.4 ± 269.9*^
Experiment 2a: Effects of increasing GluR1 on AMPAR sensitization
    Repeated saline-HSV-LacZ/saline409.5 ± 98.7462.3 ± 59.7362.8 ± 51.7
    Repeated saline-HSV-LacZ/cocaine352.8 ± 115.1422.0 ± 77.41972.5 ± 322.6*
    Repeated saline-HSV-GluR1/saline407.5 ± 72.0479.3 ± 99.9327.17 ± 82.86
    Repeated saline-HSV-GluR1/cocaine420.0 ± 117.6513.2 ± 117.82305.17 ± 452.5*
Experiment 2b: Effects of AMPA stimulation on AMPAR sensitization
    Repeated cocaine-Veh/AMPA/AMPA1263.5 ± 262.02703.4 ± 392.5506.8 ± 41.7
    Repeated cocaine-AMPA/AMPA/AMPA1293.2 ± 327.42662.2 ± 326.41859.1 ± 156.1*
Experiment 3a: Effects of dopamine agonist challenge on AMPAR sensitization
    Repeated saline-saline379.6 ± 94.7465.3 ± 64.6435.83 ± 61.7
    Repeated saline-SKF 81297382.8 ± 101.4412.0 ± 67.21015.3 ± 226.8*
    Repeated saline-quinpirole397.5 ± 71.0449.3 ± 89.9579.0 ± 96.8
    Repeated cocaine-saline1841.0 ± 420.22767.2 ± 397.5435.8 ± 165.9
    Repeated cocaine-SKF 812971822.7 ± 373.22763.3 ± 342.31229.3 ± 305.0*
    Repeated cocaine-quinpirole1799.9 ± 421.22703.0 ± 371.7459.9 ± 92.5
Experiment 3b: Effects of NAc D1 receptor blockade during cocaine challenge
    Repeated cocaine-Veh/saline1259.4 ± 285.62480.8 ± 546.5398.3 ± 75.65
    Repeated cocaine-Veh/cocaine1241.8 ± 282.22170.0 ± 192.71926.0 ± 285.7*
    Repeated cocaine-SCH 23390/cocaine1237.0 ± 234.62104.9 ± 145.1553.4 ± 172.2^
Experiment 3c: Effects of NAc AMPAR blockade during D1 agonist treatment
    Repeated cocaine-Veh/SKF 812971578.3 ± 284.82653.0 ± 214.3892.0 ± 447.1
    Repeated cocaine-CNQX/ SKF 812971621.1 ± 321.12727.8 ± 293.5924.8 ± 432.8
  • *Post hoc comparison with respective saline or vehicle (Veh)-challenged animals. ^Post hoc comparison with respective Veh/cocaine-challenged animals (p < 0.05, Fisher's LSD test).