Table 2.

Hub genes common to both AD and aging

Gene symbolADAging
Probe setAssayp valueModuleKinProbe setp valueModuleKinGene description
ATP5A1213738_s_atMMSE4.17 × 10−2Light blue0.6740096_at7.44 × 10−5Blue0.91ATP synthase alpha chain, mitochondrial
ATP6V1G2214762_atANOVA1.52 × 10−3Light blue0.8533033_at1.50 × 10−4Blue0.64Vacuolar ATP synthase subunit G 2
RAB6A210406_s_atMMSE3.05 × 10−2Light blue0.76622_at1.58 × 10−4Blue0.86RAB6A, member RAS oncogene family
YWHAZ200638_s_atMMSE3.44 × 10−3Light blue0.9734642_at1.68 × 10−6Blue0.9614-3-3 protein zeta/delta
CDK5204247_s_atMMSE3.13 × 10−3Blue0.631206_at2.28 × 10−4Blue0.64Cyclin-dependent kinase 5
PRKCB1207957_s_atANOVA2.88 × 10−4Blue0.711217_g_at1.66 × 10−5Blue0.77Protein kinase C, beta 1
DICER1213229_atCvsM1.78 × 10−2Brown0.7538764_at1.33 × 10−2Brown0.64Dicer1, Dcr-1 homolog (Drosophila)
LARP4212714_atNFT6.72 × 10−3Purple0.6435180_at2.72 × 10−2Brown0.73La ribonucleoprotein domain family member 4
  • These genes are highly connected in each data set and are highly correlated with the respective phenotype of aging or AD progression; both DICER1 and LARP4 increase expression with increasing AD progression and aging, whereas all the other hubs decrease expression with both phenotypes. The method of measuring probe set significance in AD that led to the lowest p value is presented in the AD assay column (with its associated p value). The aging p value represents the probe set's correlation with age. For both studies, kin represents the intramodular connectivity, with kin > 0.6 considered significant. In the CvsM assay, the control and moderate AD samples were compared using a t test.