Table 1.

Phasic inhibitory currents recorded in different neurons from WT and Gabra5/Gabrd−/−

WTGabra5/Gabrd−/−
CA1 PCCA3 PCDGGCCA1 PCCA3 PCDGGC
sIPSCssEPSCssIPSCssEPSCssIPSCssEPSCssIPSCssEPSCssIPSCssEPSCssIPSCssEPSCs
Imean (pA/sec)2.25 ± 0.360.37 ± 0.0411.8 ± 2.01.86 ± 0.591.96 ± 0.720.32 ± 0.032.04 ± 0.470.42 ± 0.0517.2 ± 2.982.19 ± 0.401.17 ± 0.410.32 ± 0.08
Frequency (Hz)20.8 ± 3.043.13 ± 0.7139.0 ± 3.1215.1 ± 0.8212.8 ± 3.674.84 ± 1.1020.9 ± 3.064.35 ± 0.6440.0 ± 2.1719.0 ± 2.7610.6 ± 2.452.81 ± 0.58
Peak amplitude (pA)15.8 ± 0.4014.9 ± 1.0432.6 ± 3.0419.5 ± 3.1018.4 ± 1.8612.2 ± 0.2816.2 ± 0.8714.7 ± 1.5941.9 ± 5.5920.1 ± 1.5516.5 ± 1.3811.6 ± 0.94
RT10–90 (ms)0.78 ± 0.030.81 ± 0.031.72 ± 0.091.15 ± 0.061.17 ± 0.070.88 ± 0.050.69 ± 0.030.67 ± 0.071.76 ± 0.081.22 ± 0.081.21 ± 0.080.95 ± 0.03
Tw (ms)8.45 ± 0.145.53 ± 0.369.82 ± 0.396.27 ± 0.238.05 ± 0.294.92 ± 0.148.22 ± 195.62 ± 0.1710.7 ± 0.386.65 ± 0.198.2 ± 0.344.78 ± 0.24
n558877
  • Imean, sIPSCs, and sEPSCs recorded in aCSF with a low Cl pipette solution.