Table 2.

Tonic inhibitory current recorded in the different neurons and genotypes

Tonic current (pA)CA1 PCnCA3 PCnDGGCnML interneuronsn
WT38.9 ± 5.101230.1 ± 5.28822.0 ± 5.33512.2 ± 1.6817
Gabra5−/−23.1 ± 1.751716.1 ± 2.89420.3 ± 4.03513.0 ± 2.795
Gabrd−/−36.2 ± 2.17530.9 ± 4.4056.59 ± 1.42612.0 ± 3.467
Gabra5/Gabrd−/−1.47 ± 0.5963.12 ± 1.7441.56 ± 0.2151.83 ± 1.755
WT + 50 nm L-655,70811.3 ± 3.176ndnd15.8 ± 4.15ndnd
WT + 200 nm L-655,70812.6 ± 3.566ndndndndndnd
Gabrd−/−+ 50 nm L-655,70813.2 ± 1.375ndnd1.84 ± 0.698ndnd
  • Imean, sIPSCs, and sEPSCs recorded in aCSF with a low Cl pipette solution.nd, Not determined