Table 1.

Functional and pharmacological properties of dorsal spinal currents activated by a pH drop from pH 7.4 to pH 5.0 compared with those of heterologously expressed channels in COS cells

Cell type	Current	pH_0.5 activation	pH_0.5 inactivation	Tau (s) inactivation	T_0.5 (s) reactivation	Inhibition by PcTx1	Stimulation by Zn²⁺
Neurons	Type 1 current	6.46	7.30	1.00 ± 0.06	3.59	Yes	No
	Type 2 current	6.03	6.74	0.76 ± 0.03	0.98	No	Yes
	ASIC2^−/− current	6.51	7.30	0.97 ± 0.04	5.49	Yes	No
COS cells	ASIC1a	6.37	7.30	1.12 ± 0.08	11.05	Yes	No
	ASIC2a	3.87^a	6.17	5.52 ± 0.30	0.92	No	Yes
	ASIC1a plus 2a (2:1)	6.06	6.46	0.79 ± 0.06	0.50	No	Yes
	ASIC1a plus 2a (1:1)	5.5^a		2.01 ± 0.28		No	Yes
	ASIC1a plus 2a (1:2)	5.1^b		3.53 ± 0.79		No	Yes

↵^aBaron et al., 2001.
↵^bBaron et al., 2002