Table 1.

Distribution of spheroids and vacuoles in the CNS

RegionSpheroidsVacuoles
Cuneate nucleus+++++
Gracile nucleus+++++
Trigeminal nucleus+++++
Facial nucleus+++
Cochlear nucleus+++++
Vestibular nucleus+++++
Hypoglossal nucleus++
Spinal cord dorsal horn+++++
    ventral horn++++
    dorsal funiculus++++
    ventral funiculus++++
Striatum+++
Thalamus+++
Hypothalamus+++
Hippocampus+++ (small)a
Amygdala+++
Cerebellum molecular layer+++ (small)a
    granular layer+++
    dentate nucleus++++
Cerebral cortex+ / −+++ (small)a

  • Distribution of spheroids and vacuoles in the CNS were assessed and graded as follows: +/−, very few; +, mild degree; ++, moderate degree; +++, marked degree.

  • ↵aVacuoles of small size were predominantly observed. Mice aged 95–103 weeks were examined.