Table 2.

Comparisons of severity of phenotypic features in trisomic mice

PhenotypeTs1Rhr/2NTs1Cje/2NaTs65Dn/2Na,bTs1Rhr/Ts1CjeTs1Rhr/Ts65Dn
Behavior
    Alternation task in T-maze−(0.02)−(<0.01)−(<0.01)n.s.n.s.
Neurophysiology
    LTP in control conditions−(0.01)−(<0.01)−(<0.01)n.s.n.s.
    LTP in picrotoxinn.s.n.s.n.s.n.s.n.s.
Dendritic morphology
    Fascia dentata:
        Average spine density, total−14%−12%−18%−2%+4%
            Inner ML−15%−12%−18%−3%+3%
            Middle ML−7%−12%−23%+5%+16%
            Outer ML−19%−11%−13%−8%−6%
        Average width of dendrite, total−2%+4%+9%−6%−11%
            Inner ML+3%+6%+11%−3%−8%
            Middle ML−1%+4%+7%−5%−8%
            Outer ML−4%−2%+10%−2%−14%
        Area of spine head+7%+26%+65%−19%−58%
        Length of spine neck+6%−26%−34%+32%+40%
    Layers II–III pyramidal neurons in motor cortex:
        Average spine density, layers II–III basal+11%−2%−15%+13%+26%
            Layers II–III apical+2%−6%−10%+8%+12%
            Layers II–III apical oblique+4%+13%−12%−9%−16%
        Average width of dendrite, layers II–III basal+4%+6%n.a.−2%n.a.
            Layers II–III apical−5%+10%n.a.−15%n.a.
            Layers II–III apical oblique−11%+7%n.a.−18%n.a.
        Area of spine head+17%+17%+43%0%−26%
        Length of spine neck+3%−13%−15%+16%+18%
Body weight+(<0.01)−(0.02)−(<0.01)−(0.02)+(<0.01)
Brain weight+(0.01)n.s.n.s.n.s.n.s.
  • + or − indicates increased or decreased values, respectively, of genotypic features relative to 2N or between trisomic mice. p values are shown in parenthesis. Bold represents significant difference of studied parameters. n.s., Not significant; n.a., data not available.

  • aData are from Belichenko et al. (2007).

  • bData are from Belichenko et al. (2004).