Table 2.

Plasma levels of insulin, leptin, GLP-1, and glucagon in wt and TKO mice treated intracerebroventricularly with either GLP-1 (0.75 nmol/d) or vehicle (saline) for 48 h

wtTKO
SalineGLP-1SalineGLP-1
Insulin (ng/ml)0.63 ± 0.140.33 ± 0.030.58 ± 0.240.51 ± 0.08
Leptin (ng/ml)1.88 ± 0.450.92 ± 0.13*1.75 ± 0.262.53 ± 0.83
GLP-1 (ng/ml) (total)0.21 ± 0.0314.41 ± 7.62*0.08 ± 0.0113.72 ± 6.30*
Glucagon (ng/ml)0.11 ± 0.020.15 ± 0.050.07 ± 0.020.07 ± 0.02
TG (mg/ml)2.9 ± 0.082.54 ± 0.153.07 ± 0.242.27 ± 0.12
  • Values are means ± SEM. n = 6–7 mice per group.

  • *p < 0.05 versus saline.