Knock-out | CREB/ATF family expressed in brain | Conditional expression | Viability | Major phenotypes in the nervous system | References |
---|---|---|---|---|---|
Creb1αΔ | CREBβ, CREM | Viable to adulthood | No gross abnormality of development; deficient long-term memory | Hummler et al., 1994 Bourtchuladze et al., 1994 Blendy et al., 1996b | |
Creb1−/− | CREM | Perinatal death | Enlarged ventricles; reduced commissures | Rudolph et al., 1998 | |
Crem−/− | CREB | Viable to adulthood | Circadian rhythm abnormalities; lower anxiety levels | Nantel et al., 1996 Blendy et al., 1996a Maldonado et al., 1999 | |
CrebNescre Crem−/− | Developmental (E16.5 and onward) in neuronal and glial progenitors | Perinatal death | Progressive neurodegeneration in all areas of the brain | Mantamadiotis et al., 2002 Aguado et al., 2009 | |
CrebCamkcre4 Crem−/− | Postnatal in forebrain regions | Viable to adulthood | Progressive neurodegeneration in hippocampus and striatum | Mantamadiotis et al., 2002 |