Table 1.

Dopamine depletion induced changes in receptor gene expression of striatonigral (STR-SNR) and striatopallidal (STR-GP) neurons

Cell type	Expression level		Ratio (log₂)	p value (ANOVA)	Entrez gene ID	Neurotransmitter
Cell type	Control	Lesion	Ratio (log₂)	p value (ANOVA)	Entrez gene ID	Neurotransmitter
STR-SNR	35.6	42.5	0.253	0.041	Chrna1	Acetylcholine
STR-SNR	56.7	45.1	−0.327	0.037	Gabbr1	GABA
STR-SNR	34.2	55.7	0.701	0.001	Gipr	Gip
STR-SNR	83.8	97.4	0.216	0.013	Gria1	Glutamate
STR-SNR	299.6	352.6	0.234	0.011	Gria4	Glutamate
STR-SNR	206.6	271.7	0.384	0.045	Grin1	Glutamate
STR-SNR	47.2	40.6	−0.219	0.046	Grm4	Glutamate
STR-SNR	198.6	148.1	−0.424	0.014	Grm7	Glutamate
STR-SNR	104.2	129.6	0.313	0.003	Gpr22	Orphan GPR
STR-SNR	42.6	29.3	−0.537	0.011	Gpr68	Orphan GPR
STR-SNR	440.2	810.9	0.881	2.00 × 10⁻⁵	Hrh3	Histamine
STR-SNR	167.3	211.8	0.339	0.001	Igf1r	Igf1
STR-SNR	491.9	580.5	0.238	0.013	Npr3	Natriur. peptide
STR-SNR	144.4	96.4	−0.583	0.001	Ntsr2	Neurotensin
STR-SNR	47.8	66.5	0.476	0.048	Opkr1	Opioids
STR-GP	275.6	230.8	−0.255	0.008	Adra2c	Adrenaline
STR-GP	1459.2	1806.6	0.308	0.048	Folr1	Folate
STR-GP	104.6	87.7	−0.253	0.015	Gabrb1	GABA
STR-GP	76.5	89.4	0.224	0.003	Gabrg2	GABA
STR-GP	235.6	141.5	−0.735	0.006	Gabrd	GABA
STR-GP	147.4	233.5	0.663	0.005	Grik2	Glutamate
STR-GP	146.4	102.2	−0.518	0.007	Ldlr	VLDL
STR-GP	123.5	69.7	−0.825	0.002	LOC293546	Orphan GPR
STR-SNR	83.1	101.7	0.293	0.019	GPR12	Orphan GPR
STR-GP	69.4	111.4	0.683	0.011
STR-SNR	166.1	229.6	0.434	0.013	Gucy1a3	Nitric oxide
STR-GP	244.8	168.8	−0.575	0.029
STR-SNR	104.2	60.1	−0.795	0.008	Mchr1	mch
STR-GP	103.5	125.8	0.281	0.018

GPR, G-protein-coupled receptor; Gip, gastric inhibitory polypeptide; Igf1, insulin-like growth factor; mch, melanin-concentrating hormone; Natriur., natriuretic; VLDL, very-low-density lipoprotein.