Table 2.

Whole-cell conductance, steady-state inactivation, and recovery from inactivation properties of Cav3.2 (±25) splice variants in the presence and absence of the gcm

Biophysical propertiesCav3.2 (+25)Cav3.2 (+25) gcmCav3.2 (−25)Cav3.2 (−25) gcm
Conductance
    V50−41.2 ± 1.2−43.3 ± 1.0−41.9 ± 1.2−42.6 ± 2.2
    k−7.0 ± 0.3−6.0 ± 0.3−7.0 ± 0.4−7.0 ± 0.5
    Gmax7.7 ± 0.98.6 ± 1.09.7 ± 2.07.0 ± 1.06
    Peak I density (pA/pF)−22.3 ± 3.2−30.1 ± 4.4−19.0 ± 3.5−19.4 ± 3.8
Steady-state inactivation
    V50−65.1 ± 1.2−66.1 ± 1.2−65.2 ± 1.2−67.5 ± 2.3
    k3.9 ± 0.44.1 ± 0.33.9 ± 0.44.4 ± 1.0
Recovery from inactivation
    τ 127.5 ± 2.124.1 ± 2.533.1 ± 3.825.3 ± 5.7
    τ 2745.0 ± 32.2436.8 ± 37.6*328.5 ± 35.8430.5 ± 25.3**
  • All values were calculated individually for each cell and the mean ± SEM taken to achieve the stated values (ANOVA; *p < 0.001, **p < 0.05 compared with wild-type control).