Table 1.

General physical characteristics, sensory/motor functions, depression-related behaviors, and anxiety-related behaviors of plp1 tg/− mice and Wt mice

Wtplp1tg/−
Physical characteristics
    Weight (g)28.2 (±0.6)28.0 (±0.4)
    Rectal temperature (°C)36.4 (±0.1)36.2 (±0.1)
Motor test
    Wire hang (latency to fall) (s)50.6 (±2.7)56.2 (±2.3)
    Grip strength (N)0.7 (±0.0)0.8 (±0.0)
Open field test
    Total distance for 30 min (cm)3967.4 (±269.2)3432.7 (±282.7)
    Center stay time for 30 min (s)7.3 (±0.8)8.0 (±0.7)
    Vertical activity for 30 min422.4 (±43.7)352.4 (±27.6)
Anxiety-related behavior (Light/dark test)
    Distance traveled in light (cm)909.8 (±59.4)865.5 (±67.3)
    Distance traveled in dark (cm)1382.7 (±67.2)1238.0 (±41.0)
    Light/dark transitions26.8 (±1.9)21.6 (±1.5)*
    Total time in light (s)247.2 (±13.5)257.4 (±14.8)
Pain test
    Hot plate (latency) (s)6.7 (±0.6)7.0 (±0.5)
Social interaction in novel environment
    Distance traveled (cm)3131.2 (±130.7)2972.1 (±179.9)
    Number of total contacts60.9 (±2.9)55.1 (±4.5)
    Mean duration/contact (s)1.8 (±0.2)1.7 (±0.2)
Sensory motor reflex
    Pepulse inhibition (%; startle stimulus = 110 dB)
        Prepulse intensity = 74dB40.2 (±6.4)34.2 (±7.0)
        Prepulse intensity = 78 dB56.3 (±5.1)15.0 (±20.8)#
    Pepulse inhibition (%; startle stimulus = 120 dB)
        Prepulse intensity = 74 dB27.5 (±4.7)16.3 (±5.5)
        Prepulse intensity = 78 dB39.2 (±7.8)24.6 (±5.1)#
Elevated plus-maze
    Entries into open arms (%)12.2 (±2.1)24.5 (±2.8)#
    Time spent on open arms (%)4.7 (±1.2)10.9 (±1.7)#
    Total distance traveled (cm)1439.6 (±79.2)1447.7 (±69.9)
    Total entry in arms25.3 (±1.9)28.6 (±1.9)
  • Data represent the mean (±SEM) (plp1 tg/− mice, n = 21; Wt mice, n = 21) (for social interaction; plp1 tg/− mice, n = 10; Wt mice, n = 9, n indicates number of pairs; for prepulse inhibition, plp1 tg/− mice, n = 20; Wt mice, n = 20). Statistical differences are *p < 0.05 and # p < 0.005.