The effects of cannabinoid receptor agonists and antagonist microinjected into the BLA on pain sensitivity
| Vehicle (n = 6) | AM404 (n = 6) | WIN55,212-2 (n = 6) | AM251 (n = 6) | |
|---|---|---|---|---|
| Pain threshold for foot shock (mA) | 0.36 ± 0.04 | 0.31 ± 0.03 | 0.30 ± 0.01 | 0.34 ± 0.03 |
Rats microinjected into the BLA with the CB1 receptor antagonist (AM251, n = 6), one of the agonists (WIN55,212-2 or AM404, n = 6 each), or vehicle (n = 6) showed similar pain sensitivity responses to electric footshock.