The effects of WIN 55,212-2 and the EP on locomotion and anxiety in the open-field test
| Vehicle(n = 6) | EP(n = 5) | WIN55,212-2 + EP (n = 6) | |
|---|---|---|---|
| Time in center (s) | 9.5 ± 0.76 | 7.8 ± 4.18 | 5.5 ± 1.91 |
| Time in periphery (s) | 290.5 ± 0.76 | 292.2 ± 4.18 | 294.5 ± 1.91 |
| Number of rearing events | 19.16 ± 1.25 | 10.4 ± 2.28* | 12.83 ± 1.1** |
| Distance covered (s) | 1525 ± 163.17 | 1080 ± 180.62 | 1258.33 ± 84.07 |
Rats placed on the EP (n = 5) showed increased rearing in the open-field test compared with groups that received a microinjection of vehicle (n = 6) or WIN55,212-2 before being placed on the platform (WIN_5+EP; n = 6) (*p < 0.05, vehicle group differs from WIN_5+EP group; **p < 0.01, vehicle group differs from EP group).