Summary of degree of MTSEA potentiation and calculated open probability
| Constructs | n | Degree of MTSEA potentiation | Calculated POPEN |
|---|---|---|---|
| NR2A | 7 | 2.3 ± 0.1 | 0.31 ± 0.02 |
| NR2A-ΔATD | 13 | 37 ± 2.1# | 0.02 ± 0.002 |
| NR2A-(2D-ATD) | 14 | 23 ± 3.7# | 0.04 ± 0.01 |
| NR2D | 16 | 180 ± 17 | <0.01 |
| NR2D-ΔATD | 8 | 110 ± 16# | <0.01 |
| NR2D-(2A-ATD) | 23 | 19 ± 1.9# | 0.04 ± 0.03 |
| NR2B | 8 | 16 ± 1.2 | 0.04 ± 0.003 |
| NR2B-ΔATD | 13 | 33 ± 2.4* | 0.02 ± 0.002 |
| NR2C | 10 | 790 ± 260 | <0.01 |
| NR2C-ΔATD | 8 | 210 ± 44* | <0.01 |
Values are shown with two significant digits as mean ± SEM, and n is the number of oocytes used to generate the data. POPEN values less than 0.01 reflect exceptionally low-current amplitudes prior to MTSEA application and are not reported.
↵#p < 0.01, one-way ANOVA with Bonferroni's post hoc test, compared with the corresponding wild type;
↵*p < 0.01, unpaired t test, compared with the corresponding wild type.