Table 1.

Neuropathological analysis of brains from AAV1-injected mice

Group #Group nameNumber of miceBrain weight (g)Neuron count (×106 cells)MSN cross-sectional area (μm2)
1WT-GFP130.506 ± 0.0141.331 ± 0.03087.00 ± 2.47
2YAC-GFP150.445 ± 0.006 a 0.992 ± 0.032 a 72.88 ± 1.87 a
3WT-GFP-IC10110.511 ± 0.0211.347 ± 0.02790.11 ± 1.14
4YAC-GFP-IC10140.460 ± 0.007 a 1.196 ± 0.031a,b 82.56 ± 1.90a,b
  • Four groups of mice were tested in our experiments. At 7–8 weeks of age, WT and YAC128 mice were divided into two groups each and AAV1-GFP or AAV1-GFP-IC10 injection into striatum was performed. The average brain weights, striatal neuronal counts, and striatal neuron cross-sectional areas were measured in 11.5-month-old WT and YAC128 mice at the conclusion of the behavioral trial. Several mice died following injection or during the behavioral stage of the trial and were not used in neuropathological analysis. The data are shown as mean ± SEM (n = number of mice).

  • aSignificantly different (p < 0.01) compared with WT groups.

  • bSignificantly different (p < 0.01) compared with YAC-GFP groups.