Table 1.

Genetic analysis of FXG composition and regulation

LocalizationWild-type Fmr1 null Fxr2 null
SomatodendriticFXGSomatodendriticFXGSomatodendriticFXG
FMRP+++
FXR1P++++++
FXR2P+++++
  • +, Present at wild-type levels; ++, density of granules upregulated relative to wild-type levels; −, not detected. FMRP, FXR1P, and FXR2P, were expressed in the somatodendritic region of virtually all wild-type neurons. FXGs were only detected in a subset of brain regions. FXR1P was predominantly restricted to FXGs in the cerebral cortex. See Results for details.