Table 1.

ELISA measurements of Aβ1-40 and Aβ1-42 peptide levels in M1+/+ and M1−/− APPSwe/Ind cortex at 3, 6, 12, and 16 months of age

Age
3 months(mean ± SD)6 months(mean ± SD)12 months(mean ± SD)16 months(mean ± SD)
1-40
    M1+/+318 ± 90301 ± 494221 ± 23697050 ± 9668
    M1−/−287 ± 63309 ± 1614002 ± 172641,435 ± 19806
    p value0.73960.22841.00000.0190
1–42
    M1+/+72 ± 1055 ± 2097,038 ± 77,335148,472 ± 175,542
    M1−/−69 ± 1792 ± 108100,188 ± 46,472583,435 ± 321,325
    p value0.53620.85180.90480.0381
  • Values include both SDS- and formic acid-soluble Aβ fractions and are shown as the mean ± SD of the absolute concentrations (pg/ml). At 16 months, levels of both Aβ1-40 and Aβ1-42 are increased in M1−/− mice compared to M1+/+ littermates (Aβ1-40 increased by 488%, p < 0.05; Aβ1-42 increased by 293%, p < 0.05).