Cross-sectional volumetric analyses (ANCOVA with gender and age at MRI scan as covariates) at ∼2.5 years of age for combined sample of males and females with autistic disorder compared with typically developing controls
| Autisticdisorder (n = 41) | Control(n = 44) | Significance(p value) | Percentagedifference | |
|---|---|---|---|---|
| Mean age at MRI (months) | 32 ± 9 | 30 ± 11 | 0.182 | |
| Total cerebrum (cm3) | 984 ± 76 | 920 ± 85 | 0.018* | 7% |
| Total white (cm3) | 307 ± 32 | 277 ± 47 | 0.050* | 10% |
| Total gray (cm3) | 676 ± 59 | 643 ± 54 | 0.046* | 5% |
| Frontal gray (cm3) | 232 ± 24 | 218 ± 19 | 0.038* | 6% |
| Temporal gray (cm3) | 142 ± 14 | 131 ± 13 | 0.008** | 9% |
| Cingulate gray (cm3) | 26 ± 3 | 24 ± 3 | 0.097 | 8% |
| Parietal gray (cm3) | 165 ± 15 | 160 ± 15 | 0.289 | 4% |
| Occipital gray (cm3) | 80 ± 8 | 78 ± 9 | 0.225 | 3% |