Table 4.

Results of best-fit mixed-effects model analyses in a combined sample of males and females with autistic disorder compared with typically developing controls

Region	Gender	Linear age	Diagnosis	Diagnosis × linear age	Quadratic age	Diagnosis × quadratic age
Total cerebrum	0.003^{^a}	<0.0001^{^a}	0.222	0.546	<0.0001^{^a}	<0.001^{^a}
Total white	0.111	<0.0001^{^a}	0.713	0.264	<0.0001^{^a}	0.051^{^a}
Total gray	0.002^{^a}	<0.0001^{^a}	0.133	0.839	0.002^{^a}	0.073^{^a}
Frontal gray	0.002^{^a}	<0.0001^{^a}	0.027^{^a}
Temporal gray	0.007^{^a}	<0.0001^{^a}	0.008^{^a}	0.972	0.062	0.058^{^a}
Cingulate gray	0.120	<0.0001^{^a}	0.464	0.959	<0.0001^{^a}	0.010^{^a}
Parietal gray	0.053	<0.0001^{^a}	0.647	0.352	0.008^{^a}	0.027^{^a}
Occipital gray	0.001^{^a}	<0.0001^{^a}	0.620		0.009^{^a}

Bold indicates a significant difference between autistic disorder and control.
↵^aSignificant effect.