Table 2.

Action potential properties in P35 Mecp2 wild-type and null mice

Mecp2 wild typeMecp2 null
Peak amplitude (mV)67.32 ± 2.3867.58 ± 2.88
Afterhyperpolarization (mV)−18.93 ± 1.46−24.27 ± 2.50
Half-width (ms)1.19 ± 0.130.91 ± 0.07
Threshold (mV)−34.66 ± 2.32−32.22 ± 1.30
Rise time (10–90%, ms)0.59 ± 0.070.51 ± 0.07
Rise slope (10–90%, mV/ms)119.44 ± 15.87119.94 ± 11.18
Decay time (90–10%, ms)1.02 ± 0.120.67 ± 0.06*
Decay slope (90–10%, mV/ms)−61.96 ± 5.98−91.76 ± 11.10*
  • Action potential properties were determined from current-induced depolarization. Data are derived from the initial action potential elicited at threshold.

  • *p < 0.05, t test. Data are mean ± SEM for wild type (n = 13 cells) and null (n = 15 cells).