Table 2.

Summary of EEG results

Single spikeDouble spikesTriple spikesSpike-wave discharges
Amp (μV)Fr (n/h)Amp (μV)Fr (n/h)Amp (μV)Fr (n/h)Amp (μV)Fr (n/h)Duration (s) (range)
BACE1−/−221.4 ± 61.220.0 ± 5.4228.6 ± 54.32.4 ± 0.3211.2 ± 54.52.0 ± 0.398.8 ± 9.240 ± 8.622.2 ± 36.5 (1–230)
BACE1+/+178.6 ± 54.34.5 ± 1.2000
  • Spike-wave discharges are defined as three or more single spikes scored within the period of 1 s. Mean ± SD of amplitude (Amp), frequencies (Fr), and duration (in seconds) of the discharges are displayed. Frequencies are defined as the average occurrence of discharges per hour. The baseline of EEG in BACE1-null mice was ∼50 μV, whereas that of wild-type mice was ∼20 μV.