Summary of literature supporting increase in specific synaptic weights with the advance of Parkinson's disease
| Weight | Literature supporting weight increase in Parkinson's disease |
|---|---|
| wSG | Dopamine reduces the effect of glutamate on GPe neurons (Johnson and Napier, 1997; Kita, 2007) |
| D2 receptors are present in GPe (Hoover and Marshall, 2004; Kita, 2007) | |
| wGS | In the parkinsonian state, GABA agonists in GPe evokes greater currents in STN (Shen and Johnson, 2005) |
| Dopamine reduces the effect of GABA on STN neurons (Cragg et al., 2004) | |
| D2 receptors are present in STN (Shen and Johnson, 2000) | |
| wGG | Increased ambient GABA in GPe in animal models of Parkinson's disease (Robertson et al., 1991; Ochi et al., 2000; Schroeder and Schneider, 2002) |
| D2 receptors are present in GPe (Hoover and Marshall, 2004; Kita, 2007) | |
| wCS | In the parkinsonian state, STN neurons are excited to a greater extent by cortex (Magill et al., 2001) |
| In the parkinsonian state, AMPA and NMDA currents are greater in the STN (Shen and Johnson, 2005) | |
| D2 receptors are present in STN (Shen and Johnson, 2000) | |
| wXG | Striatal neurons activity is increased after dopamine depletion (Kish et al., 1999; Tseng et al., 2001; O'Donnell, 2003) |
| D2 receptors reduce the excitability of striatopallidal neurons (Obeso et al., 2000; Surmeier et al., 2007) | |
| Increased GPe ambient GABA in animal models of Parkinson's disease (Robertson et al., 1991; Ochi et al., 2000; Schroeder and Schneider, 2002) | |
| D2 receptors are present in GPe (Hoover and Marshall, 2004; Kita, 2007) | |
| Striatopallidal neurons are activated by dopamine lesion (Mallet et al., 2006) |
The indexes of the weights refer to the origin and target nuclei of the connection they describe, and these can be C (cortex), X (striatum), S (STN), or G (GPe).