Table 1.

Analysis 2: relationships between cue-evoked anticipatory responses and pain-processing network mediator activity

Brain regionCoordinates (mm)No. of voxels (p < 0.001)Volume (mm)PPNM a × b effectPPNM cov(a,b)Insula a × b effectThalamus a × b effectrdACC a × b effect
Medial OFC−460−140.7952 (0.18)**10160.7952 (0.18)**1.39770.8566 (0.51)0.748 (0.25)**0.9488 (0.32)**
Right ventral striatum−104−140.3345 (0.09)**8080.3345 (0.09)**0.86080.5048 (0.004)**0.3092 (0.16)*0.4471 (0.03)*
  • This table presents results from analysis 2, presented as a path diagram in Figure 7. Activity was averaged across pain processing network mediators (rdACC, left anterior insula, and right thalamus), and we searched for regions whose cue-evoked responses during medium trials mediated cue effects on average PPNM responses during pain. We then tested the relationship between each anticipatory mediator and the three PPNM regions. This table presents results for medial OFC and right ventral striatum, which were the only regions whose anticipatory cue-evoked responses positively mediated cue effects on pain-evoked responses in all three PPNMs.

  • *p < 0.05,

  • **p < 0.01,

  • p = 0.0818.