Summary of the main CORT effects on frontal cortex (top) and hippocampus (bottom) of rats treated with saline (SAL) or LPS
| SAL | LPS | |||||||
|---|---|---|---|---|---|---|---|---|
| PRO | Mixed | NO | ANT | PRO | Mixed | NO | ANT | |
| Cortex | ||||||||
| NF-κ B | ✓ | ✓ | ||||||
| IL-1β | ✓ | ✓ | ||||||
| TNF-α | ✓ | ✓ | ||||||
| Iκ B-α | ✓ | ✓ | ||||||
| IL-1ra | ✓ | ✓ | ||||||
| MKP-1 | ✓ | ✓ | ||||||
| 42/44 MAPK | ✓ | ✓ | ||||||
| SAPK/JNK | ✓ | ✓ | ||||||
| p38 MAPK | ✓ | ✓ | ||||||
| AKT | ✓ | ✓ | ||||||
| Hippocampus | ||||||||
| NF-κ B | ✓ | ✓ | ||||||
| IL-1β | ✓ | ✓ | ||||||
| TNF-α | ✓ | ✓ | ||||||
| Iκ B-α | ✓ | ✓ | ||||||
| IL-1ra | ✓ | ✓ | ||||||
| MKP-1 | ✓ | ✓ | ||||||
| 42/44 MAPK | ✓ | ✓ | ||||||
| SAPK/JNK | ✓ | ✓ | ||||||
| p38 MAPK | ✓ | ✓ | ||||||
| AKT | ✓ | ✓ | ||||||
PRO, Proinflammatory effects for all CORT levels; Mixed, pro- and anti-inflammatory effects dose-dependent; NO, no CORT effects in any level; ANTI, anti-inflammatory effects for all CORT levels.