Table 1.

Monkeys' WM condition on behavioral test before killing

Animal groups and their treatmentsWM statusa
Amphetamine young animal group
    Vehicle controlNormal
    Amphetamine treatmentDeficit
    Amphetamine-treated animals 6 mo after withdrawalRecuperated to normal
Haloperidol young animal group
    Vehicle controlNormal
    Haloperidol treatmentDeficit
    Haloperdol-treated animals after D1 agonist administrationRecuperated to normal
Haloperidol aged animal group
    Vehicle controlNormal
    Haloperidol treatmentDeficit
  • aThe WM status was determined by the results of animal performance on spatial delayed response shown in Figure 1A. Animals with significant reduction in the percentage of correct choices were considered to be WM deficient.