Table 2.

Mean percentage depletions of 5-HT, DA, and NA (± SEM) in the striatum and anterior cortices of marmosets with 5,7-DHT or 6-OHDA infusions into the caudate nucleus

Caudate dopamine depletionsCaudate 5-HT depletions
DA5-HTNA5-HTDANA
Medial head of caudate14.67 ± 11.3424.91 ± 20.21−3.99 ± 43.0466.68 ± 12.1*−16.73 ± 5.587.57 ± 40.38
Lateral head of caudate−35.94 ± 25.15−2.15 ± 28.9433.17 ± 27.4229.50 ± 9.89−41.6 ± 6.95*60.36 ± 11.9*
Caudate body−5.73 ± 6.1938.55 ± 16.73−0.77 ± 35.6534.98 ± 3.43*−11.54 ± 12.4151.36 ± 25.67
Nucleus accumbens5.72 ± 22.1710.63 ± 33.012.77 ± 27.131.69 ± 34.26−4.51 ± 11.69−8.90 ± 28.22
Putamen−1.02 ± 22.1725.02 ± 23.5319.03 ± 27.18−14.92 ± 33.76−19.03 ± 17.121.48 ± 13.82
Lateral PFC15.02 ± 12.0333.67 ± 27.1514.86 ± 19.4922.49 ± 18.055.29 ± 13.68−19.1 ± 14.67
OFC−7.31 ± 26.4114.96 ± 21.144.86 ± 10.04−7.30 ± 22.2814.14 ± 18.58−23.79 ± 21.14
Medial PFC25.92 ± 9.1136.87 ± 14.5711.39 ± 22.40−29.08 ± 24.1924.80 ± 13.32−36.63 ± 23.04
Dorsal PFC11.68 ± 4.8045.57 ± 19.2530.90 ± 22.2914.08 ± 20.283.45 ± 16.88−23.72 ± 23.33
Motor cortex18.65 ± 10.9339.11 ± 24.8825.18 ± 11.8921.93 ± 11.30−4.02 ± 3.13−19.62 ± 14.49
Anterior cingulate44.87 ± 12.5*41.08 ± 18.4525.38 ± 15.763.81 ± 31.4611.11 ± 8.22−25.48 ± 15.88
Midcingulate35.86 ± 7.29*35.88 ± 25.9520.85 ± 21.6258.07 ± 11.7*−5.87 ± 10.32−4.06 ± 13.95
Anterior–parietal41.63 ± 0.51*46.21 ± 26.6443.39 ± 15.2753.08 ± 13.689.39 ± 12.23−15.07 ± 6.74
  • Significant percentage changes are highlighted in bold; − indicates a percentage increase.

  • *p < 0.05.