Effects of 5 mg/kg GBR 12909, naloxone, and their combination on measures of attentional function, compulsivity, and motivation in the 5-CSRTT
| Treatment | Accuracy (%) | Perseverative responses | Response latency (ms) | Omissions | Feeder latency (ms) |
|---|---|---|---|---|---|
| Vehicle–vehicle | 85.0 ± 1.5 | 14.4 ± 2.1 | 310 ± 8 | 9.1 ± 2.1 | 1716 ± 178 |
| GBR–vehicle | 82.2 ± 1.9 | 17.1 ± 3.9 | 292 ± 8 | 7.7 ± 1.4 | 1990 ± 343 |
| GBR–NAL (1 mg/kg) | 85.4 ± 1.7 | 18.9 ± 3.8 | 302 ± 7 | 9.2 ± 2.7 | 2216 ± 339 |
| GBR–NAL (3 mg/kg) | 84.8 ± 2.1 | 16.7 ± 3.3 | 304 ± 9 | 11.5 ± 2.2 | 2017 ± 350 |
In total, n = 15 animals were included in the analyses, and data depict mean ± SEM. GBR, GBR 12909; NAL, naloxone.